Detalhe da pesquisa
1.
Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation.
Chem Res Toxicol
; 28(10): 1991-9, 2015 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26351880
2.
Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.
Bioorg Med Chem Lett
; 23(11): 3175-9, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23628336
3.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
4.
Selective non zinc binding inhibitors of MMP13.
Bioorg Med Chem Lett
; 21(14): 4215-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21669521
5.
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Bioorg Med Chem
; 18(21): 7486-96, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869876
6.
A simple in vitro assay for assessing the reactivity of nitrile containing compounds.
Bioorg Med Chem Lett
; 19(4): 1136-8, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168354
7.
Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
Bioorg Med Chem Lett
; 19(16): 4832-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19574045
8.
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 19(6): 1658-61, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19231183
9.
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
ACS Med Chem Lett
; 9(8): 809-814, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128072
10.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem
; 61(9): 3823-3841, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683659
11.
Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
J Med Chem
; 49(23): 6672-82, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154498
12.
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
ACS Med Chem Lett
; 7(1): 94-9, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819673
13.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020862
14.
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J Med Chem
; 58(8): 3522-33, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25790336
15.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407012
16.
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
J Med Chem
; 57(21): 8984-98, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25286150
17.
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
J Med Chem
; 55(11): 5361-79, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22545772
18.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641
19.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem
; 55(20): 8827-37, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984809
20.
Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J Med Chem
; 59(7): 3576, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27003331